A monocytic leukemia case with t(9;11) translocation and CD14/CD64 positivity. Which AML subtype is this?

Get ready for the CAMLPR Hematology Test. Use our quizzes, flashcards, and detailed explanations to enhance your understanding. Prepare confidently for your exam!

Multiple Choice

A monocytic leukemia case with t(9;11) translocation and CD14/CD64 positivity. Which AML subtype is this?

The key idea is monocytic differentiation in AML. When blasts show monocytic markers like CD14 and CD64 and the case carries a translocation commonly seen in monocytic leukemias, the diagnosis aligns with acute monocytic leukemia. The t(9;11) rearrangement is a recurrent genetic change associated with monocytic variants, and CD14 and CD64 positivity specifically point to monocytic lineage. That combination fits the M5 category. Other subtypes differ: M3 is acute promyelocytic leukemia (often with t(15;17)); M4 is myelomonocytic and shows both myeloid and monocytic features but not as tightly linked to t(9;11); M0 is poorly differentiated with no clear lineage markers. So the case describes acute monocytic leukemia, M5.

The key idea is monocytic differentiation in AML. When blasts show monocytic markers like CD14 and CD64 and the case carries a translocation commonly seen in monocytic leukemias, the diagnosis aligns with acute monocytic leukemia. The t(9;11) rearrangement is a recurrent genetic change associated with monocytic variants, and CD14 and CD64 positivity specifically point to monocytic lineage. That combination fits the M5 category. Other subtypes differ: M3 is acute promyelocytic leukemia (often with t(15;17)); M4 is myelomonocytic and shows both myeloid and monocytic features but not as tightly linked to t(9;11); M0 is poorly differentiated with no clear lineage markers. So the case describes acute monocytic leukemia, M5.

More practice questions