Aspirin’s effect on hemostasis is to which of the following?

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Multiple Choice

Aspirin’s effect on hemostasis is to which of the following?

Aspirin’s effect on hemostasis comes from its action on platelets. It irreversibly inhibits cyclooxygenase-1 in platelets, which stops the production of thromboxane A2, a key driver of platelet activation and aggregation. With less thromboxane A2, platelets don’t clump together as well at a site of vascular injury, so primary hemostasis is impaired and bleeding time is prolonged. It does not increase platelet production, it does not activate the coagulation cascade, and it does not promote fibrinolysis.

Aspirin’s effect on hemostasis comes from its action on platelets. It irreversibly inhibits cyclooxygenase-1 in platelets, which stops the production of thromboxane A2, a key driver of platelet activation and aggregation. With less thromboxane A2, platelets don’t clump together as well at a site of vascular injury, so primary hemostasis is impaired and bleeding time is prolonged. It does not increase platelet production, it does not activate the coagulation cascade, and it does not promote fibrinolysis.

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