Dark staining coarse cytoplasmic granules in neutrophils are characteristic of which anomaly?

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Multiple Choice

Dark staining coarse cytoplasmic granules in neutrophils are characteristic of which anomaly?

Dark staining coarse cytoplasmic granules in neutrophils point to Alder-Reilly anomaly. These granules arise from lysosomal storage of partially degraded mucopolysaccharides, due to a defect in their degradation. The result is large, dark, persistent inclusions in neutrophils (and often monocytes), which can be seen even in the absence of infection. This distinguishes Alder-Reilly from other neutrophil abnormalities: May-Hegglin anomaly features Dohle-like basophilic inclusions and often enlarged platelets; Chediak-Higashi syndrome shows giant lysosome-like granules in multiple cell types along with albinism and immune defects; Pseudo-Pelger-Huët anomaly presents with bilobed or hyposegmented neutrophil nuclei rather than cytoplasmic granules.

Dark staining coarse cytoplasmic granules in neutrophils point to Alder-Reilly anomaly. These granules arise from lysosomal storage of partially degraded mucopolysaccharides, due to a defect in their degradation. The result is large, dark, persistent inclusions in neutrophils (and often monocytes), which can be seen even in the absence of infection. This distinguishes Alder-Reilly from other neutrophil abnormalities: May-Hegglin anomaly features Dohle-like basophilic inclusions and often enlarged platelets; Chediak-Higashi syndrome shows giant lysosome-like granules in multiple cell types along with albinism and immune defects; Pseudo-Pelger-Huët anomaly presents with bilobed or hyposegmented neutrophil nuclei rather than cytoplasmic granules.

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