Factor V Leiden mutation results in which of the following?

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Multiple Choice

Factor V Leiden mutation results in which of the following?

Resistance to activated protein C from a Factor V Leiden mutation allows Factor Va to stay active longer, boosting thrombin generation. Factor Va is a cofactor in the prothrombinase complex with Factor Xa that converts prothrombin to thrombin; activated protein C normally inactivates Factor Va to limit thrombin production. The Leiden mutation makes Factor Va resistant to this inactivation, so more thrombin is produced, promoting clot formation. This mechanism explains why Factor V Leiden increases risk of venous thrombosis. The other options don’t fit because this mutation does not increase platelet production, decrease fibrinogen synthesis, or enhance antithrombin activity.

Resistance to activated protein C from a Factor V Leiden mutation allows Factor Va to stay active longer, boosting thrombin generation. Factor Va is a cofactor in the prothrombinase complex with Factor Xa that converts prothrombin to thrombin; activated protein C normally inactivates Factor Va to limit thrombin production. The Leiden mutation makes Factor Va resistant to this inactivation, so more thrombin is produced, promoting clot formation. This mechanism explains why Factor V Leiden increases risk of venous thrombosis. The other options don’t fit because this mutation does not increase platelet production, decrease fibrinogen synthesis, or enhance antithrombin activity.

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