G20210A mutation leads to which of the following?

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Multiple Choice

G20210A mutation leads to which of the following?

The mutation at this site in the prothrombin gene increases circulating prothrombin levels, which leads to more thrombin generation during coagulation. More thrombin drives clot formation, so venous thromboembolism risk, including DVT, goes up. That’s why the statement about elevated prothrombin and increased DVT risk is the best fit. It does not decrease prothrombin, nor does it directly boost plasminogen activation or reduce Factor VIII activity, so those options don’t match the effect of this mutation.

The mutation at this site in the prothrombin gene increases circulating prothrombin levels, which leads to more thrombin generation during coagulation. More thrombin drives clot formation, so venous thromboembolism risk, including DVT, goes up. That’s why the statement about elevated prothrombin and increased DVT risk is the best fit. It does not decrease prothrombin, nor does it directly boost plasminogen activation or reduce Factor VIII activity, so those options don’t match the effect of this mutation.

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