G20210A mutation occurs in which gene?

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Multiple Choice

G20210A mutation occurs in which gene?

The G20210A mutation is in the prothrombin gene (F2). This G-to-A change at nucleotide 20210, located in the 3' region of F2, leads to higher circulating prothrombin levels, increasing thrombin generation and the risk of venous thromboembolism. This differs from the Factor V gene mutation (which is G1691A and causes activated protein C resistance), and from mutations in tissue factor or plasminogen genes, which are not the site of this variant. So the gene carrying G20210A is the prothrombin gene.

The G20210A mutation is in the prothrombin gene (F2). This G-to-A change at nucleotide 20210, located in the 3' region of F2, leads to higher circulating prothrombin levels, increasing thrombin generation and the risk of venous thromboembolism. This differs from the Factor V gene mutation (which is G1691A and causes activated protein C resistance), and from mutations in tissue factor or plasminogen genes, which are not the site of this variant. So the gene carrying G20210A is the prothrombin gene.

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