In CML, the leukocyte alkaline phosphatase (LAP) score is typically:

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Multiple Choice

In CML, the leukocyte alkaline phosphatase (LAP) score is typically:

The leukocyte alkaline phosphatase (LAP) score reflects the enzymatic activity in circulating neutrophils. In chronic myeloid leukemia, the malignant neutrophil population is dysregulated and functionally abnormal, leading to reduced alkaline phosphatase activity, so the LAP score is typically low. This contrast with a leukemoid reaction, where neutrophils are actively responding to infection or inflammation and LAP is elevated. Thus, a low LAP supports CML over a reactive process. LAP isn’t used to diagnose polycythemia vera, which involves red cell mass rather than neutrophil enzyme activity. Note that during effective treatment, LAP can rise toward normal as neutrophil function improves.

The leukocyte alkaline phosphatase (LAP) score reflects the enzymatic activity in circulating neutrophils. In chronic myeloid leukemia, the malignant neutrophil population is dysregulated and functionally abnormal, leading to reduced alkaline phosphatase activity, so the LAP score is typically low. This contrast with a leukemoid reaction, where neutrophils are actively responding to infection or inflammation and LAP is elevated. Thus, a low LAP supports CML over a reactive process. LAP isn’t used to diagnose polycythemia vera, which involves red cell mass rather than neutrophil enzyme activity. Note that during effective treatment, LAP can rise toward normal as neutrophil function improves.

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