In renal disease–related anemia, reticulocyte count is typically which of the following?

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Multiple Choice

In renal disease–related anemia, reticulocyte count is typically which of the following?

In renal disease–related anemia, the reticulocyte count is typically decreased. This happens because the kidneys produce erythropoietin, the hormone that stimulates the bone marrow to make red blood cells. When kidney function is impaired, erythropoietin production falls, so the bone marrow isn’t adequately stimulated to increase erythropoiesis. The result is fewer reticulocytes released into the bloodstream for a given level of anemia, reflecting a hypoproliferative, rather than regenerative, response. Treatments that provide erythropoietin can raise the reticulocyte count as marrow stimulation returns.

In renal disease–related anemia, the reticulocyte count is typically decreased. This happens because the kidneys produce erythropoietin, the hormone that stimulates the bone marrow to make red blood cells. When kidney function is impaired, erythropoietin production falls, so the bone marrow isn’t adequately stimulated to increase erythropoiesis. The result is fewer reticulocytes released into the bloodstream for a given level of anemia, reflecting a hypoproliferative, rather than regenerative, response. Treatments that provide erythropoietin can raise the reticulocyte count as marrow stimulation returns.

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