In the basophil lineage, which cell becomes mast cells in tissue?

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Multiple Choice

In the basophil lineage, which cell becomes mast cells in tissue?

Mast cells in tissues come from bone marrow–derived progenitors that travel to tissues and differentiate along the basophil lineage into tissue mast cells. This linking to the basophil pathway explains why a basophil–lineage cell is the one that becomes a mast cell once it settles in tissue and matures under local signals like SCF. The other options are earlier granulocytic precursors or a neutrophil-stage cell and do not participate in the basophil-to-mast cell maturation path, so they don’t become tissue mast cells.

Mast cells in tissues come from bone marrow–derived progenitors that travel to tissues and differentiate along the basophil lineage into tissue mast cells. This linking to the basophil pathway explains why a basophil–lineage cell is the one that becomes a mast cell once it settles in tissue and matures under local signals like SCF.

The other options are earlier granulocytic precursors or a neutrophil-stage cell and do not participate in the basophil-to-mast cell maturation path, so they don’t become tissue mast cells.

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