Lupus anticoagulants are antibodies that inhibit the APTT reagent and are identified using which test?

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Multiple Choice

Lupus anticoagulants are antibodies that inhibit the APTT reagent and are identified using which test?

Lupus anticoagulants are antiphospholipid antibodies that bind phospholipid–protein complexes and interfere with phospholipid-dependent coagulation reactions, so they prolong clotting times in vitro even though they’re associated with thrombosis in vivo. Because the Russell’s Viper Venom Test uses venom to activate the coagulation cascade in a way that relies on a phospholipid surface, the presence of lupus anticoagulants delays the venom-induced clotting. This makes RVVT a sensitive and specific way to detect lupus anticoagulants, which is why it’s used for identification. The other ideas don’t capture this mechanism: they describe different antibody effects or aren’t the testing approach used to reveal lupus anticoagulants.

Lupus anticoagulants are antiphospholipid antibodies that bind phospholipid–protein complexes and interfere with phospholipid-dependent coagulation reactions, so they prolong clotting times in vitro even though they’re associated with thrombosis in vivo. Because the Russell’s Viper Venom Test uses venom to activate the coagulation cascade in a way that relies on a phospholipid surface, the presence of lupus anticoagulants delays the venom-induced clotting. This makes RVVT a sensitive and specific way to detect lupus anticoagulants, which is why it’s used for identification. The other ideas don’t capture this mechanism: they describe different antibody effects or aren’t the testing approach used to reveal lupus anticoagulants.

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