The most common inherited bleeding disorder is von Willebrand disease. What is a typical treatment?

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Multiple Choice

The most common inherited bleeding disorder is von Willebrand disease. What is a typical treatment?

Desmopressin works by triggering endothelial cells to release stored von Willebrand factor and factor VIII into the bloodstream, temporarily boosting their levels. This boosts platelet adhesion and clot formation, addressing the core defect in many patients with the common inherited form of von Willebrand disease (usually type 1 with mild deficiency). It’s especially useful as a first-line treatment before minor procedures or to treat a bleed in patients who are responsive to DDAVP. Other options don’t specifically raise von Willebrand factor levels: fresh frozen plasma provides variable and unpredictable vWF content and carries more risks; prothrombin complex and factor IX concentrate don’t address the vWF deficiency.

Desmopressin works by triggering endothelial cells to release stored von Willebrand factor and factor VIII into the bloodstream, temporarily boosting their levels. This boosts platelet adhesion and clot formation, addressing the core defect in many patients with the common inherited form of von Willebrand disease (usually type 1 with mild deficiency). It’s especially useful as a first-line treatment before minor procedures or to treat a bleed in patients who are responsive to DDAVP. Other options don’t specifically raise von Willebrand factor levels: fresh frozen plasma provides variable and unpredictable vWF content and carries more risks; prothrombin complex and factor IX concentrate don’t address the vWF deficiency.

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