What cell morphology is characteristic of Sezary syndrome?

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Multiple Choice

What cell morphology is characteristic of Sezary syndrome?

Cerebriform lymphocytes are the hallmark of Sezary syndrome. These malignant CD4+ T cells in the peripheral blood have highly folded, convoluted nuclei that resemble brain gyri, giving them a cerebral or cerebriform appearance. Their presence in blood, often with erythroderma and generalized lymphadenopathy, points to Sezary syndrome as a leukemic form of cutaneous T-cell lymphoma. Other morphologies described here reflect different diseases: Auer rods are needle-like inclusions in myeloblasts seen in acute myeloid leukemia; rouleaux formation is stacks of red cells often seen with abnormal plasma proteins; Dutcher bodies are immunoglobulin inclusions in plasma cells, seen in plasma cell dyscrasias. These do not characterize Sezary syndrome.

Cerebriform lymphocytes are the hallmark of Sezary syndrome. These malignant CD4+ T cells in the peripheral blood have highly folded, convoluted nuclei that resemble brain gyri, giving them a cerebral or cerebriform appearance. Their presence in blood, often with erythroderma and generalized lymphadenopathy, points to Sezary syndrome as a leukemic form of cutaneous T-cell lymphoma.

Other morphologies described here reflect different diseases: Auer rods are needle-like inclusions in myeloblasts seen in acute myeloid leukemia; rouleaux formation is stacks of red cells often seen with abnormal plasma proteins; Dutcher bodies are immunoglobulin inclusions in plasma cells, seen in plasma cell dyscrasias. These do not characterize Sezary syndrome.

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