What is the correct activation order for the common pathway?

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Multiple Choice

What is the correct activation order for the common pathway?

In the common pathway, activation starts with factor X being converted to Xa. Xa, with its cofactor Va, forms the prothrombinase complex that converts prothrombin (factor II) into thrombin. Thrombin then acts to turn fibrinogen (factor I) into fibrin and also activates factor XIII to XIIIa, which crosslinks the fibrin to stabilize the clot. Because Xa’s activation initiates the process, followed by formation of the prothrombinase complex (requiring Va), then thrombin formation (activation of II to IIa), and finally the activation of XIII and the conversion of I to fibrin, the activation sequence is X, V, II, XIII, I.

In the common pathway, activation starts with factor X being converted to Xa. Xa, with its cofactor Va, forms the prothrombinase complex that converts prothrombin (factor II) into thrombin. Thrombin then acts to turn fibrinogen (factor I) into fibrin and also activates factor XIII to XIIIa, which crosslinks the fibrin to stabilize the clot. Because Xa’s activation initiates the process, followed by formation of the prothrombinase complex (requiring Va), then thrombin formation (activation of II to IIa), and finally the activation of XIII and the conversion of I to fibrin, the activation sequence is X, V, II, XIII, I.

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