What is the most common chromosomal defect found in myelodysplastic syndromes?

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Multiple Choice

What is the most common chromosomal defect found in myelodysplastic syndromes?

Deletion of the long arm of chromosome 5 is the most common chromosomal defect seen in myelodysplastic syndromes. This specific deletion, often referred to as del(5q), appears as the single most frequent abnormality among MDS cytogenetics and helps define a recognizable subset of patients. Isolated del(5q) cases tend to have a relatively better prognosis compared with other cytogenetic abnormalities and respond well to targeted therapy like lenalidomide. Other abnormalities listed, such as loss of the entire chromosome 5, the Philadelphia translocation t(9;22), or other deletions like del(7q), can occur in MDS but are less common than del(5q) and have different clinical implications.

Deletion of the long arm of chromosome 5 is the most common chromosomal defect seen in myelodysplastic syndromes. This specific deletion, often referred to as del(5q), appears as the single most frequent abnormality among MDS cytogenetics and helps define a recognizable subset of patients. Isolated del(5q) cases tend to have a relatively better prognosis compared with other cytogenetic abnormalities and respond well to targeted therapy like lenalidomide. Other abnormalities listed, such as loss of the entire chromosome 5, the Philadelphia translocation t(9;22), or other deletions like del(7q), can occur in MDS but are less common than del(5q) and have different clinical implications.

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