Where do T cells differentiate compared to B cells?

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Multiple Choice

Where do T cells differentiate compared to B cells?

The starting idea is that T cells and B cells mature in different primary lymphoid organs. T cells finish their development in the thymus, where they undergo T cell receptor gene rearrangement and undergo positive and negative selection to ensure they recognize self MHC and are non-reactive to self. B cells finish maturation in the bone marrow, where they rearrange their immunoglobulin genes and undergo quality checks before entering peripheral circulation. This separation explains why the correct description is that T cells differentiate in the thymus and B cells differentiate in the bone marrow.

The starting idea is that T cells and B cells mature in different primary lymphoid organs. T cells finish their development in the thymus, where they undergo T cell receptor gene rearrangement and undergo positive and negative selection to ensure they recognize self MHC and are non-reactive to self. B cells finish maturation in the bone marrow, where they rearrange their immunoglobulin genes and undergo quality checks before entering peripheral circulation. This separation explains why the correct description is that T cells differentiate in the thymus and B cells differentiate in the bone marrow.

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