Which antigens are identified in T-cell CLL?

Get ready for the CAMLPR Hematology Test. Use our quizzes, flashcards, and detailed explanations to enhance your understanding. Prepare confidently for your exam!

Multiple Choice

Which antigens are identified in T-cell CLL?

The important idea here is that immunophenotyping defines the lineage of the leukemic cells. In T-cell CLL, the malignant cells express T-lineage surface antigens. The best choice lists CD2, CD3, CD5, and CD6, which are all markers associated with T cells. CD2 and CD3 are classic indicators of T-cell lineage, CD5 is commonly present on T cells, and CD6 is another T-cell–associated molecule. This combination supports a T-cell origin for the CLL. In contrast, the other options mix markers that either aren’t characteristic of mature T cells in this context or don’t form a coherent T-cell profile, so they don’t fit the typical T-cell CLL immunophenotype.

The important idea here is that immunophenotyping defines the lineage of the leukemic cells. In T-cell CLL, the malignant cells express T-lineage surface antigens. The best choice lists CD2, CD3, CD5, and CD6, which are all markers associated with T cells. CD2 and CD3 are classic indicators of T-cell lineage, CD5 is commonly present on T cells, and CD6 is another T-cell–associated molecule. This combination supports a T-cell origin for the CLL.

In contrast, the other options mix markers that either aren’t characteristic of mature T cells in this context or don’t form a coherent T-cell profile, so they don’t fit the typical T-cell CLL immunophenotype.

More practice questions