Which antigens are identified in B-cell chronic lymphocytic leukemia?

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Multiple Choice

Which antigens are identified in B-cell chronic lymphocytic leukemia?

B-cell chronic lymphocytic leukemia is identified by a distinctive B-cell immunophenotype on flow cytometry: the malignant cells are mature B lymphocytes that express CD19 and CD20, but also co-express CD5, which is unusual for B cells. CD22 is commonly present as well, and CD23 is often positive too. So the pattern of CD5 with CD19 and CD20 (plus CD22) is characteristic of CLL and helps distinguish it from other B-cell neoplasms that lack CD5 or show different marker combinations. If a panel shows mainly T-cell markers (such as CD2, CD3, CD4, CD7, or CD8) or omits CD5 with B-cell markers, it would not fit the CLL phenotype.

B-cell chronic lymphocytic leukemia is identified by a distinctive B-cell immunophenotype on flow cytometry: the malignant cells are mature B lymphocytes that express CD19 and CD20, but also co-express CD5, which is unusual for B cells. CD22 is commonly present as well, and CD23 is often positive too. So the pattern of CD5 with CD19 and CD20 (plus CD22) is characteristic of CLL and helps distinguish it from other B-cell neoplasms that lack CD5 or show different marker combinations. If a panel shows mainly T-cell markers (such as CD2, CD3, CD4, CD7, or CD8) or omits CD5 with B-cell markers, it would not fit the CLL phenotype.

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