Which combination of additional testing supports the erythroleukemia diagnosis?

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Multiple Choice

Which combination of additional testing supports the erythroleukemia diagnosis?

Erythroleukemia involves proliferation of erythroid precursors along with a myeloid blast component, so evidence of both lineages strengthens the diagnosis. Erythroid cells in the marrow typically stain positive with PAS due to glycogen-rich cytoplasm, pointing to the erythroid component. The accompanying myeloid blasts show myeloid markers such as myeloperoxidase (MPO) positivity (and can also be Sudan Black positive). Seeing both PAS positivity (erythroid lineage) and MPO positivity (myeloid lineage) supports a dual-lineage leukemia consistent with erythroleukemia. If you only observed one lineage marker, it wouldn’t establish the erythroid–myeloid combination characteristic of this entity.

Erythroleukemia involves proliferation of erythroid precursors along with a myeloid blast component, so evidence of both lineages strengthens the diagnosis. Erythroid cells in the marrow typically stain positive with PAS due to glycogen-rich cytoplasm, pointing to the erythroid component. The accompanying myeloid blasts show myeloid markers such as myeloperoxidase (MPO) positivity (and can also be Sudan Black positive). Seeing both PAS positivity (erythroid lineage) and MPO positivity (myeloid lineage) supports a dual-lineage leukemia consistent with erythroleukemia. If you only observed one lineage marker, it wouldn’t establish the erythroid–myeloid combination characteristic of this entity.

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