Which diagnosis is suggested by >20% megakaryoblasts with CD41/CD42 positivity and inv(3) on cytogenetics?

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Multiple Choice

Which diagnosis is suggested by >20% megakaryoblasts with CD41/CD42 positivity and inv(3) on cytogenetics?

Megakaryoblastic differentiation defines this leukemic process. When blasts are more than 20% and express platelet/megakaryocyte markers like CD41 and CD42, the blasts are of megakaryocytic lineage rather than myeloid or lymphoid. The inv(3)(q21q26) cytogenetic abnormality is a classic association with acute myeloid leukemia that has megakaryoblastic features, often denoting that specific lineage and prognosis. Put together, these findings point to Acute Megakaryoblastic Leukemia (M7). Other leukemias would not characteristically show the combination of megakaryocytic markers and inv(3).

Megakaryoblastic differentiation defines this leukemic process. When blasts are more than 20% and express platelet/megakaryocyte markers like CD41 and CD42, the blasts are of megakaryocytic lineage rather than myeloid or lymphoid. The inv(3)(q21q26) cytogenetic abnormality is a classic association with acute myeloid leukemia that has megakaryoblastic features, often denoting that specific lineage and prognosis. Put together, these findings point to Acute Megakaryoblastic Leukemia (M7). Other leukemias would not characteristically show the combination of megakaryocytic markers and inv(3).

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