Which electrophoresis pattern is consistent with hemoglobin C disease?

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Multiple Choice

Which electrophoresis pattern is consistent with hemoglobin C disease?

In hemoglobin electrophoresis, the pattern reflects which hemoglobins are being produced. In hemoglobin C disease (HbCC), the body makes mostly HbC, and there is no HbA or HbS produced. HbF is typically minimal. So the telltale pattern is HbC as the predominant hemoglobin with only trace HbF and little to no HbA or HbS. This distinguishes it from sickle cell disease (HbS predominates with little/no HbA), normal adult Hb (HbA predominates), or beta-thalassemia traits (which show elevated HbA2, not HbC dominance).

In hemoglobin electrophoresis, the pattern reflects which hemoglobins are being produced. In hemoglobin C disease (HbCC), the body makes mostly HbC, and there is no HbA or HbS produced. HbF is typically minimal. So the telltale pattern is HbC as the predominant hemoglobin with only trace HbF and little to no HbA or HbS. This distinguishes it from sickle cell disease (HbS predominates with little/no HbA), normal adult Hb (HbA predominates), or beta-thalassemia traits (which show elevated HbA2, not HbC dominance).

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