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Multiple Choice

Which erythroid precursor is described as having a peripheral nucleus?

As erythroid cells mature, the nucleus becomes smaller and is pressed toward the edge of the cell as hemoglobin accumulates and the cell prepares to eject its nucleus. The stage where the nucleus is highly condensed and often seen at the cell’s periphery, with cytoplasm colored by hemoglobin, is the orthochromatic erythroblast. This is the final nucleated precursor before enucleation, signaling that the cell is about to become a reticulocyte. Earlier stages have larger, centrally located nuclei (proerythroblast and basophilic erythroblast), and the polychromatic erythroblast still shows a larger nucleus with mixed cytoplasmic tint. So, the peripheral, condensed nucleus is characteristic of the orthochromatic erythroblast.

As erythroid cells mature, the nucleus becomes smaller and is pressed toward the edge of the cell as hemoglobin accumulates and the cell prepares to eject its nucleus. The stage where the nucleus is highly condensed and often seen at the cell’s periphery, with cytoplasm colored by hemoglobin, is the orthochromatic erythroblast. This is the final nucleated precursor before enucleation, signaling that the cell is about to become a reticulocyte. Earlier stages have larger, centrally located nuclei (proerythroblast and basophilic erythroblast), and the polychromatic erythroblast still shows a larger nucleus with mixed cytoplasmic tint. So, the peripheral, condensed nucleus is characteristic of the orthochromatic erythroblast.