Which factors are vitamin K dependent?

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Multiple Choice

Which factors are vitamin K dependent?

Vitamin K enables gamma-carboxylation of specific glutamate residues on several coagulation factors, allowing them to bind calcium and assemble on phospholipid surfaces to promote clotting. The factors that undergo this VK-dependent modification are prothrombin (factor II), stable factor (VII), Christmas factor (IX), and Stuart-Prower factor (X). These are the classic vitamin K–dependent factors. Fibrinogen (I), factor V, and factor VIII do not require vitamin K for activation, and factor III is tissue factor, not a plasma vitamin K–dependent coagulation factor. So the set II, VII, IX, X is the correct one. (Note: proteins C and S are also vitamin K–dependent, but they’re not listed here.)

Vitamin K enables gamma-carboxylation of specific glutamate residues on several coagulation factors, allowing them to bind calcium and assemble on phospholipid surfaces to promote clotting. The factors that undergo this VK-dependent modification are prothrombin (factor II), stable factor (VII), Christmas factor (IX), and Stuart-Prower factor (X). These are the classic vitamin K–dependent factors. Fibrinogen (I), factor V, and factor VIII do not require vitamin K for activation, and factor III is tissue factor, not a plasma vitamin K–dependent coagulation factor. So the set II, VII, IX, X is the correct one. (Note: proteins C and S are also vitamin K–dependent, but they’re not listed here.)

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