Which markers are positive by flow cytometry in this case?

Get ready for the CAMLPR Hematology Test. Use our quizzes, flashcards, and detailed explanations to enhance your understanding. Prepare confidently for your exam!

Multiple Choice

Which markers are positive by flow cytometry in this case?

Flow cytometry identifies cell lineages by their surface proteins. Platelets and their precursor megakaryocytes specifically carry CD41 (GPIIb) and CD42 (GPIb-IX-V). When these markers are positive, it points to the platelet/megakaryocytic lineage. In contrast, CD3 and CD19 mark T and B lymphocytes, MPO marks myeloid/myeloblasts, and CD56 marks NK cells (and some T-cell subsets). Therefore, positivity for CD41 and CD42 best identifies platelets, making that combination the correct choice.

Flow cytometry identifies cell lineages by their surface proteins. Platelets and their precursor megakaryocytes specifically carry CD41 (GPIIb) and CD42 (GPIb-IX-V). When these markers are positive, it points to the platelet/megakaryocytic lineage. In contrast, CD3 and CD19 mark T and B lymphocytes, MPO marks myeloid/myeloblasts, and CD56 marks NK cells (and some T-cell subsets). Therefore, positivity for CD41 and CD42 best identifies platelets, making that combination the correct choice.

More practice questions