Which of the following is NOT used to treat high titre inhibitors (>5 BU)?

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Multiple Choice

Which of the following is NOT used to treat high titre inhibitors (>5 BU)?

Desmopressin is not effective for high-titer factor VIII inhibitors because it works by releasing endogenous FVIII from endothelial stores. When inhibitor levels are high, the newly released FVIII is rapidly neutralized, so there’s little to no meaningful rise in FVIII activity. In contrast, steroids can dampen the immune response, IVIG can modulate the antibody-mediated process, and plasmapheresis can physically remove inhibitors from circulation. These approaches address the immune problem directly or reduce inhibitors, making them viable in high-titer scenarios.

Desmopressin is not effective for high-titer factor VIII inhibitors because it works by releasing endogenous FVIII from endothelial stores. When inhibitor levels are high, the newly released FVIII is rapidly neutralized, so there’s little to no meaningful rise in FVIII activity. In contrast, steroids can dampen the immune response, IVIG can modulate the antibody-mediated process, and plasmapheresis can physically remove inhibitors from circulation. These approaches address the immune problem directly or reduce inhibitors, making them viable in high-titer scenarios.

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