Which staining result is positive in the ALL L1 case?

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Multiple Choice

Which staining result is positive in the ALL L1 case?

Periodically Schiff (PAS) positivity reflects glycogen-rich cytoplasm characteristic of lymphoid blasts. In ALL, especially the L1 subtype with small, uniform blasts, PAS staining is typically strong, making it a helpful clue that these cells are lymphoid rather than myeloid. Myeloid markers like myeloperoxidase and Sudan Black would be positive in myeloid leukemias, not in typical ALL blasts, and platelet peroxidase points to megakaryocytic/platelet lineage, which is also not seen in standard ALL L1. Therefore, PAS positivity is the staining pattern you'd expect in ALL L1.

Periodically Schiff (PAS) positivity reflects glycogen-rich cytoplasm characteristic of lymphoid blasts. In ALL, especially the L1 subtype with small, uniform blasts, PAS staining is typically strong, making it a helpful clue that these cells are lymphoid rather than myeloid. Myeloid markers like myeloperoxidase and Sudan Black would be positive in myeloid leukemias, not in typical ALL blasts, and platelet peroxidase points to megakaryocytic/platelet lineage, which is also not seen in standard ALL L1. Therefore, PAS positivity is the staining pattern you'd expect in ALL L1.

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