Which staining result is positive in the ALL L2 case?

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Multiple Choice

Which staining result is positive in the ALL L2 case?

Periodic acid–Schiff highlights carbohydrate-rich substances in cells. In ALL blasts, especially the L2 subtype, the cytoplasm contains abundant glycogen and other polysaccharides, so the lymphoblasts take up PAS and appear magenta. This PAS positivity is a classic feature of lymphoid blasts and helps distinguish them from myeloid blasts, which typically show positivity for myeloid markers like MPO or Sudan Black. While PAS results can vary, the typical profile for ALL L2 includes PAS positivity, making it the best indicator among the options.

Periodic acid–Schiff highlights carbohydrate-rich substances in cells. In ALL blasts, especially the L2 subtype, the cytoplasm contains abundant glycogen and other polysaccharides, so the lymphoblasts take up PAS and appear magenta. This PAS positivity is a classic feature of lymphoid blasts and helps distinguish them from myeloid blasts, which typically show positivity for myeloid markers like MPO or Sudan Black. While PAS results can vary, the typical profile for ALL L2 includes PAS positivity, making it the best indicator among the options.

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