Which statement best describes the action of Thrombin Activatable Fibrinolysis Inhibitor?

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Multiple Choice

Which statement best describes the action of Thrombin Activatable Fibrinolysis Inhibitor?

Thrombin Activatable Fibrinolysis Inhibitor slows down the breakdown of a clot. It’s a carboxypeptidase that, when activated by thrombin (in the thrombin-thrombomodulin complex), removes C-terminal lysine residues from fibrin. Those lysine sites are key docking points for plasminogen and tissue plasminogen activator; with fewer docking sites, plasmin formation and fibrinolysis are reduced. So the action described is inhibition of fibrinolysis, not promotion of clot formation or direct blocking of plasminogen activation. This makes the described role a precise negation of fibrinolysis.

Thrombin Activatable Fibrinolysis Inhibitor slows down the breakdown of a clot. It’s a carboxypeptidase that, when activated by thrombin (in the thrombin-thrombomodulin complex), removes C-terminal lysine residues from fibrin. Those lysine sites are key docking points for plasminogen and tissue plasminogen activator; with fewer docking sites, plasmin formation and fibrinolysis are reduced. So the action described is inhibition of fibrinolysis, not promotion of clot formation or direct blocking of plasminogen activation. This makes the described role a precise negation of fibrinolysis.

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