Which statement best describes the effect of increased 2,3-DPG production on the oxygen dissociation curve?

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Multiple Choice

Which statement best describes the effect of increased 2,3-DPG production on the oxygen dissociation curve?

2,3-DPG binds to deoxygenated hemoglobin and stabilizes the T state, lowering hemoglobin’s affinity for oxygen. When its production increases, the oxygen dissociation curve shifts to the right, meaning a higher PO2 is needed to achieve the same saturation (P50 rises). As a result, hemoglobin releases oxygen more readily to tissues at a given PO2. This is why increased 2,3-DPG reduces oxygen affinity. It does not change the iron content of hemoglobin.

2,3-DPG binds to deoxygenated hemoglobin and stabilizes the T state, lowering hemoglobin’s affinity for oxygen. When its production increases, the oxygen dissociation curve shifts to the right, meaning a higher PO2 is needed to achieve the same saturation (P50 rises). As a result, hemoglobin releases oxygen more readily to tissues at a given PO2. This is why increased 2,3-DPG reduces oxygen affinity. It does not change the iron content of hemoglobin.

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